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Tramadol undergoes hepatic metabolism via the cytochrome P450 isozyme CYP2D6, as O and N-demethylated five different metabolites. Of these, M1 is the most important because it 200 times? - The proximity of (+) - get, and the elimination half life of nine hours, compared to six hours to get itself. In 6% of the population, which is slowly CYP2D6 activity, and slightly reduced analgesic effect. Phase II liver metabolism is water soluble metabolites, and they are displayed on the kidneys. Thus, reducing doses can be used in renal and hepatic view.
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